Member-only story

Antimicrotubule Agents: A Comprehensive Chemotherapy Review Series

Jacob Foster

·2.2k Followers· Follow

Published in Antimicrotubule Agents: Chemotherapy Comprehensive Review Series: 7

3 min read · 1 month before

582 View Claps

30 Respond

Save

Listen

Antimicrotubule agents: Chemotherapy comprehensive review series: 7

Antimicrotubule agents: Chemotherapy comprehensive review series: book 7

by Maha Alkurdi

5 out of 5

Language	:	English
File size	:	444 KB
Text-to-Speech	:	Enabled
Screen Reader	:	Supported
Enhanced typesetting	:	Enabled
Print length	:	49 pages
Lending	:	Enabled

Microtubules are essential for cell division, and their inhibition is a common target for chemotherapeutic drugs. Antimicrotubule agents are a class of chemotherapeutic drugs that inhibit the assembly or function of microtubules, leading to cell death.

Types of Antimicrotubule Agents

There are two main types of antimicrotubule agents:

* **Vinca alkaloids** (e.g., vinblastine, vincristine) bind to tubulin and inhibit its polymerization. * **Taxanes** (e.g., paclitaxel, docetaxel) bind to tubulin and stabilize it, preventing its disassembly.

Mechanisms of Action

Antimicrotubule agents inhibit the assembly or function of microtubules by different mechanisms. Vinca alkaloids bind to tubulin and inhibit its polymerization, while taxanes bind to tubulin and stabilize it, preventing its disassembly. Both of these mechanisms lead to the disruption of the mitotic spindle, which is essential for cell division.

Clinical Applications

Antimicrotubule agents are used to treat a variety of cancers, including:

* Breast cancer * Lung cancer * Ovarian cancer * Lymphoma * Leukemia

Antimicrotubule agents are typically used in combination with other chemotherapeutic drugs, and they can be given intravenously or orally.

Side Effects

The most common side effects of antimicrotubule agents include:

* Neutropenia * Anemia * Thrombocytopenia * Nausea * Vomiting * Diarrhea * Constipation * Peripheral neuropathy

Antimicrotubule agents are a class of chemotherapeutic drugs that inhibit the assembly or function of microtubules, leading to cell death. They are used to treat a variety of cancers, and they are typically used in combination with other chemotherapeutic drugs.

Antimicrotubule agents: Chemotherapy comprehensive review series: book 7

by Maha Alkurdi

5 out of 5